📰 The molecular effects of caffeine in the brain

Scientists are deciphering the molecular mechanisms underlying the effects of caffeine in the brain. This work, carried out in mice and published in the journal The Journal of Clinical Investigation, reinforce the idea of ​​a beneficial effect of caffeine (Caffeine is an alkaloid of the methylxanthine family, present in many…) on cognitive functions.

Caffeine is the most widely consumed psychoactive substance in world (The word world can refer to:). While its effects on vigilance (His attention takes on an aspect of intensity to solicit all of his capacities for…) and attention are widely known, the brain molecular mechanisms associated with its regular consumption remained little known until now.


Chronic treatment of mice with caffeine induced (The armature is a generally electromagnetic device used in electrical engineering responsible for…) concerted epigenetic changes in neuronal and non-neuronal cells, which underlie a decrease in metabolism (Metabolism is the set of molecular and energetic transformations…) (energetic and lipid) and an increase in genes and proteins involved in neuronal signaling and plasticity. This is followed by fine-tuning of the metabolism (fine-tuning) and an increase in the capacity of neurons to respond (priming) to a task oflearning (Learning is the acquisition of know-how, i.e. the process…) spatial.
© I Paiva, AL Boutillier, D Blum, Biorender

Scientists demonstrate in mice that habitual caffeine consumption induces lasting molecular changes in the hippocampus, a structure essential for memory (Generally speaking, memory is the storage of information. It is also remembering…) and which degenerates into sickness (Disease is an alteration of the functions or health of a living organism, animal…) of Alzheimer’s. The results obtained by different methods combining genomics (Genomics is a discipline of modern biology. It studies how…), metabolomics and proteomics suggest that caffeine promotes the processing of information in this structure in response to a learning task, by exerting a concerted action on neuronal and non-neuronal cells. Caffeine significantly modifies the hippocampal epigenome in a differentiated way depending on whether it is neuronal or non-neuronal cells. This helps to promote the molecular processes associated with memory.

This study provides evidence experimental (In art, these are creative approaches based on questioning dogmas…) of a link between caffeine consumption and the neural processes involved in memory and encourages us to decipher more precisely the molecular effects of caffeine on the different brain cells and to better understand the caffeine/memory link inman (A man is an adult male individual of the species called Modern Man (Homo…). In particular, a potential beneficial effect in patients with Alzheimer’s disease is currently theobject (In general, the word object (from the Latin objectum, 1361) designates an entity defined in…) of the’clinical test (A clinical trial is a scientific study carried out in therapy…) ACAFC (NCT04570085).

To know more:
Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription.
Paiva I, Cellai L, Meriaux C, Poncelet L, Nebie O, Saliou JM, Lacoste AS, Papegaey A, Drobecq H, Le Gras S, Schneider M, Malik EM, Müller CE, Faivre E, Carvalho K, Gomez-Murcia V , Vieau D, Thiroux B, Eddarkaoui S, Lebouvier T, Schueller E, Tzeplaeff L, Grgurina I, Seguin J, Stauber J, Lopes LV, Buée L, Buée-Scherrer V, Cunha RA, Ait-Belkacem R, Sergeant N, Annicotte JS, Boutillier AL, Blum D.
The Journal of Clinical Investigation May 10, 2022. https://doi.org/10.1172/JCI149371.

Laboratory:
– Lille Neuroscience (The neurosciences correspond to the set of all biological disciplines and…) & Cognition. (University of Lille/Inserm). University Hospital of Lille. street (The street is a circulation space in the city that serves housing and places…) Polonovski, 59000 Lille.
– Laboratory of cognitive and adaptive neurosciences (LNCA). CNRS/University of Strasbourg. Faculty of Psychology. 12 rue Goethe. 67000 Strasbourg.

contacts:
-David Blum- Searcher (A researcher (fem. researcher) refers to a person whose job is to do research…) Inserm in Lille neuroscience & cognition – david.blum at inserm.fr
– Anne-Laurence Boutillier – Researcher CNRS (The National Center for Scientific Research, better known by its acronym CNRS, is the largest…) at the Laboratory of Cognitive and Adaptive Neurosciences. LNCA (CNRS/University of Strasbourg) – laurette at unistra.fr

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